Abstract
A new series of cysLT1 receptor antagonists represented by CP-288,886 (7) and CP-265,298 (8) were developed which are equipotent to clinical cysLT1 receptor antagonists Zafirlukast (1) and Pranlukast (2).
MeSH terms
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Animals
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Anti-Asthmatic Agents / chemical synthesis*
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Anti-Asthmatic Agents / pharmacokinetics
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Anti-Asthmatic Agents / pharmacology
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Biological Availability
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Guinea Pigs
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Humans
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Leukotriene Antagonists*
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Magnetic Resonance Spectroscopy
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Membrane Proteins*
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Quinolines / chemical synthesis*
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Quinolines / pharmacokinetics
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Quinolines / pharmacology
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Rats
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Receptors, Leukotriene*
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Stereoisomerism
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacokinetics
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Thiazoles / pharmacology
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U937 Cells
Substances
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Anti-Asthmatic Agents
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CP 265298
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Leukotriene Antagonists
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Membrane Proteins
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Quinolines
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Receptors, Leukotriene
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Thiazoles
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CP 288886
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cysteinyl leukotriene receptor 2
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leukotriene D4 receptor